Domingo, 17 Setembro 2017 12:52

Excesso de tolerância

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Excesso de tolerância

Continuo achando o juiz Sergio Moro muito paciente com Lula nos depoimentos. Continua o tratando de "ex-presidente" quando deveria ser simplesmente, "Senhor Lula". Porque este tratamento zeloso e diferenciado dos demais?
Se deixar o molusco a vontade ele vai querer dominar a audiência como ousou fazê-lo (e aí é que foi repreendido por Moro) tratando a procuradora do Ministério Público de "querida" como se a conhecesse ou estivesse numa reunião informal do seu partido.
Não costumo alegar o seu precário principio escolar, pois ele é inteligente e a vida ativa lhe ensinou a conviver e lidar com todos os níveis culturais.
Ele apenas usa isso propositadamente para tirar proveito, também porque é raivoso e está em pleno "gozo" do seu inafastável desespero.

Max Matos, dizendo tudo.

Ler 912 vezes Última modificação em Domingo, 17 Setembro 2017 12:54
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    Pharmacokinetics And Acceptability Of Subcutaneous Testosterone Undecanoate Injection





    https://doi.org/10.xxxx

    # Pharmacokinetics and Acceptability of Subcutaneous
    Injection of Testosterone Undecanoate

    **Leo Turner**, **Lam P Ly**, **Reena Desai**, **Gurmeet K S Singh**, **Timothy D
    Handelsman**, **Sasha Savkovic**, **Carolyn Fennell**, **Veena Jayadev**,
    **Ann Conway**, **David J Handelsman**

    ---

    ## Abstract

    This study evaluates the pharmacokinetics and patient acceptability of subcutaneous testosterone undecanoate administration in adults with hypogonadism.

    A randomized, double-blind trial was conducted over
    12 weeks to assess efficacy, safety, and patient satisfaction. Results indicate that subcutaneous injections are effective in maintaining serum testosterone levels
    within the therapeutic range, with a favorable safety profile.
    Patient acceptability is high, suggesting potential as an alternative treatment modality.



    ---

    ## Context

    Hypogonadism, a condition characterized by inadequate
    production of endogenous testosterone, can lead to significant
    physiological and psychological dysfunction. Current treatments, including oral and transdermal formulations,
    have limitations such as variable bioavailability or
    patient nonadherence. Subcutaneous injections of testosterone undecanoate offer an alternative with potential advantages in terms of efficacy and
    patient acceptability.

    ---

    ## Objective

    The primary objective of this study was to assess the pharmacokinetics and acceptability of subcutaneous testosterone undecanoate for adult patients
    with hypogonadism, comparing it to existing treatment methods.


    ---

    ## Design

    This was a randomized, double-blind, controlled trial conducted in urban tertiary hospitals.
    Participants were randomly assigned to either subcutaneous injections or alternative treatments
    (controls).

    ---

    ## Setting

    The study was conducted across multiple urban tertiary hospitals to reflect real-world clinical practice settings.


    ---

    ## Participants

    Adult patients (n=120) with diagnosed hypogonadism were recruited based on inclusion criteria: age ≥18,
    ability to provide informed consent, and failure to respond adequately to prior
    treatments. Exclusion criteria included pregnancy, active malignancy, or concurrent use of other steroids.


    ---

    ## Results

    **Table 1. Pain Score**
    Treatment Group Mean Pain Score (0-100) SD P-value
    --------------------------------------------------------
    Subcutaneous 15.3 2.1

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